Diltiazem overdose effects. Survival depends on how much and what type of this medicine the person took and how quickly they receive treatment. Four fatal cases of diltiazem overdose are described and compared with previously published cases. Clinical sequelae include all grades of heart block, hypotension and ultimately death. Hence, the onset of toxicity can be delayed by several hours and the duration of toxicity can be prolonged owing to ongoing absorption from the GI tract. Death can occur, especially with verapamil. Aug 6, 2023 · Diltiazem is used to treat high blood pressure, angina and certain heart rhythm disorders. Jul 28, 2023 · Reported adverse effects of therapy in high doses and multiple administrations include acute pancreatitis, ARDS, interference with vasopressors, and fat overload syndrome inducing hepatosplenomegaly, seizures, fat embolism, and coagulopathy. Events observed following Diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure. gov Mar 11, 2024 · Some side effects of diltiazem may occur that usually do not need medical attention. Felodipine Felodipine is highly protein-bound and exhibits a half-life of 11-16 hours. . These side effects may go away during treatment as your body adjusts to the medicine. Both agents are commonly available in sustained‐release (SR) formulations. Sep 3, 2025 · Calcium channel blockers (CCBs) are used in the treatment of hypertension, angina pectoris, cardiac arrhythmias, and other disorders. Included diltiazem side effects, interactions and indications. Severe calcium channel blocker toxicity is highly lethal, as a result of cardiovascular collapse. Because of protein binding, the drug’s elimination is prolonged. Good outcomes can be achieved through aggressive treatment and provision of circulatory support. 1-2–1-9 The diagnosis of diltiazem overdose is based on clinical features affecting the central nervous system (for example, confusion, lethargy, coma, respiratory arrest Verapamil and diltiazem are the CCBs most commonly implicated in severe CVS toxicity following overdose. Management includes gastric lavage and oral administration of Discussion Diltiazem is a calcium channel antagonist, which causes vasodilation and has negative chronotropic, dromotropic, and inotropic properties. Taking too much of a calcium-channel blocker can be very dangerous. Amlodipine’s long duration of action increases the risk of morbidity and mortality from an overdose. 1-2 Reports of diltiazem overdose are rare but well documented. If the person's heart rate and blood pressure can be corrected, survival is likely. These medications are available in both immediate-release and extended-release preparations; the latter are in wide clinical use (figure 1) [1]. The clinical effects of amlodipine are similar to those of nicardipine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Most reports of overdose described some supportive medical measure and/or drug treatment. Calcium channel blockers overdose can cause life-threatening effects, such as bradycardia, atrioventricular (AV) block, hypotension, metabolic acidosis, and shock that is often refractory to conventional therapy. See full list on medlineplus. 5hg1iu 08ot 3qa 05hxh 3hv qdo16gmc um er ychr t7o